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SYNERGY-NASH: Tirzepatide and metabolic steatohepatitis (MASH) SYNERGY-NASH (Loomba et al., NEJM 2024, NEJMoa2401943, PMID 38856224) is a phase 2 trial in 190 patients with metabolic steatohepatitis (MASH) and biopsy-proven stage 2 or 3 fibrosis

Ensure proper site rotation (not injecting the same spot repeatedly), use alcohol swabs consistently, and inject at room temperature (taking the vial out 15 to 20 minutes before injection can help)

The full dose is usually not initially prescribed with the injections and is worked up to over several weeks

If you reconstituted on February 11, your discard date is March 11

We review contraindications (personal or family history of thyroid cancer, pancreatitis, severe GI conditions)

In all KO genotypes, cFos induction in the AP and NTS was markedly blunted compared to WT mice, establishing that both AMY1R and AMY3R are necessary for transmitting cagrilintides central effects